Modeling Therapy-Induced Tumor Cell State Plasticity to Identify Vulnerabilities for Reducing Disease Burden
A Talk by Jonathan A. Kelber (Department of Biology, California State University Northridge (CSUN), Los Angeles, California)
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About this Talk
Intracellular and intercellular signaling events in the tumor microenvironment that contribute to disease progression and targeted therapy resistance remain poorly understood, presenting significant clinical hurdles. Recent efforts in our laboratory have focused on identifying and characterizing the mechanisms by which subpopulations of aggressive and/or intervention-refractory cancer cells emerge within solid tumors. Single-cell protein/phosphoprotein and in vitro/in vivo data will be discussed that identify targetable vulnerabilities which may be leveraged to overcome therapy resistance and improve patient outcomes.